by Allison Wenzel
Gas chromatography (GC) is an essential technique used in many industries, including pharmaceuticals, to analyze compounds and their purity. In pharmaceuticals, GC instrumentation and analysis play a critical role in ensuring the quality and safety of drug products.
Excite Pharma, a CDMO (Contract Development Manufacturing Organization) company, utilizes GC to analyze residual solvents, drug purity and detect contaminants within drug products.
Gas Chromatography separates compounds by first injecting either a gas or a liquid sample into the inlet. The vaporized compounds are then carried through the column by an inert gas where the compounds will interact with the stationary phase of the column and further separate from each other. From there the separated compounds within a drug product will travel and arrive at the detector in example Flame Ionized Detector (FID) where a signal is produced and analyzed.
Historically, Gas Chromatography has had several advances in technology. From packed columns to capillary columns, to the invention and utilization of several different detectors. Gas Chromatography is widely adaptable, sensitive and with the application of Head Space Extraction or Mass Spectrometry, can further separate and identify an analyte of interest.
GC instrumentation and analysis play a critical role in the overall process of helping Excite Pharma’s clients with their products.
In combination with Excite Pharma’s stability program, GC instrumentation is employed to aid in determining shelf life, storage conditions and any potential environmental factors such as temperature, humidity and photostability. By performing degradation studies on a drug product, a GC can also illustrate what potential harmful compounds a drug product when degraded can produce.
GC instrumentation and analysis are essential in the pharmaceutical industry and Excite Pharma’s GC services provide several benefits to their clients. These include the ability to ensure that products are maintaining their quality, and detecting harmful degradation products or contaminants. Clients can trust Excite Pharma’s high-sensitivity GC to provide accurate results.
One unique aspect of Excite Pharma’s GC services is the application of Head Space Extraction to its GC analysis. Volatile analytes are removed from a sample matrix by taking advantage of the volatile analyte’s lower boiling point and transferred to a GC for analysis. Some benefits found in Head Space Extraction Instrumentation include increased sensitivity and extraction from large complex matrices. GC instrumentation and analysis play a critical role in ensuring the quality and safety of drug products. Excite Pharma’s high-sensitivity GC, provide several benefits to their clients, such as accurate detection of residual solvents, impurities, and degradation products.
Clients can trust Excite Pharma’s GC services to ensure that their product meets safety standards and is effective. Use the form below to let us know how we can help with your GC needs.
